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复方阿尔维林合用酪酸梭菌治疗肠易激综合征的疗效评价
引用本文:胡宝春,李华富,罗伟聪. 复方阿尔维林合用酪酸梭菌治疗肠易激综合征的疗效评价[J]. 国际医药卫生导报, 2009, 15(1): 52-56. DOI: 10.3760/cma.j.issn.1007-1245.2009.01.021
作者姓名:胡宝春  李华富  罗伟聪
作者单位:武警广东总队医院消化内科,广州,510507;武警广东总队医院消化内科,广州,510507;武警广东总队医院消化内科,广州,510507
摘    要:目的观察复方构橼酸阿尔维林胶囊合用酪酸梭菌活菌胶囊治疗肠易激综合征的近期疗效。方法采用随机对照方法,将81例IBS病人随机分成A组和B组,A组病例给予复方枸橼酸阿尔维林软胶囊1粒,每日3次;B组给予匹维溴铵片50mg,每日3次。两组都口服酪酸梭菌活菌胶囊1.26g,每日2次。分别于第2周末和第4周末观察病人腹痛、腹胀、腹泻、便秘等情况,并据此评价各组的疗效。结果第2周末疗效评定,A组和B组的总有效率分别为70.7%和65.0%,差别没有显著性差异(P〉0.05);第4周末疗效评定,两组总有效率分别为88.6%和81.8%(P〉0.05)。就单项症状而言,第2周末对腹痛、腹泻的疗效,两组差别无显著意义(P〉0.05);对腹胀的疗效A组明显优于B组(P〈0.01);对便秘B组优于A组但差异无统计学意义(P〉0.05)。第4周末四种症状的疗效均无显著性差异(P〉0.05);3、第4周末A、B两组总有效率高于第2周末,但是差异无显著性意义。结论复方枸橼酸阿尔维林合用酪酸梭菌活菌胶囊可以有效缓解IBS病人的临床症状,近期疗效明显。治疗需要一定的疗程,4周疗程比2周疗程效果好。

关 键 词:复方枸橼酸阿尔维林胶囊  酪酸梭菌活菌胶囊  匹维溴铵  肠易激综合征

Evaluation on clinical therapeutic efficacy of compound alverine citrate and clostridium butyricum on irritable bowel syndrome
HU Bao-chun,LI Hua-fu,LUO Wei-cong. Evaluation on clinical therapeutic efficacy of compound alverine citrate and clostridium butyricum on irritable bowel syndrome[J]. International Medicine & Health Guidance News, 2009, 15(1): 52-56. DOI: 10.3760/cma.j.issn.1007-1245.2009.01.021
Authors:HU Bao-chun  LI Hua-fu  LUO Wei-cong
Affiliation:HU Bao-chun, LI Hua-fu, LEO Wei-cong( Guangdong Corps Hospital, Chinese People's Armed Police Force, Guangzhou 510507, China)
Abstract:Objective To observe and evaluate the efficacy of compound alverine citrate with capsule of clostridium butyricum live in the treatment of IBS. Methods 81 patients with IBS were divided into 2 groups randomly. Patients in group A (41 cases) were treated orally with capsule of compound alverine citrate (Meteospasmyl, one capsule, 3 times a day) and capsule of clostridium butyricum live (Ataining, 1.26, twice a day),while those in group B (40 cases) were given orally pinaverium bromide (Dicetel, 50 mg, 3 times a day) for 4 weeks. A observation and evaluation on the change of such symptoms as abdominal pain, abdominal bulge, diarrhea, or constipation was performed respectively at the end of 2nd and 4th week of therapeutic period. Results The total effective rates were 70.7% and 88.6% at the end of 2nd and 4th week of the medication period respectively in group A, and those in group B were 65.0% and 81.8% simultaneously. There was no significant difference (P>0.05) between the efficacy of group A and B, neither after 2 weeks' treatment nor after 4 weeks' treatment. However, at 2nd week, the improvement of abdominal bulge symptom in group A was better than in group B (P<0.01). Conclusions Compound alverine citrate and capsule of clostridium butyricum live can be used in the treatment of IBS with a definite therapeutic effect.
Keywords:Compound alverine citrate  Meteospasmyl  Clostridium butyricum  Pinaverium bromide  Irritable bowel syndrome
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