妊娠合并系统性红斑狼疮孕妇的妊娠时机及对妊娠结局的影响（附25例临床资料分析）

目的：探讨影响妊娠合并系统性红斑狼疮（SLE）妊娠结局的相关因素，提出SLE患者最佳受孕时机和孕期的治疗监护，预防妊娠合并SLE的恶化及SLE对妊娠的不良影响，以提高围产质量。方法回顾性分析25例妊娠合并SLE的临床资料。结果25例妊娠合并SLE患者，14例病情处于缓解期或控制期的患者，仅1例双胎妊娠发生早产，新生儿窒息0例，1例孕妇狼疮性肾炎加重，子痫前期0例；11例病情未控制或有SLE活动者，发生早产4例，新生儿窒息2例，孕期发生狼疮性肾炎3例，血小板减少3例，子痫前期2例。结论SLE患者应首先控制疾病的活动，在产科医师及风湿免疫科医师的指导下受孕，妊娠期加强胎儿监护及SLE疾病的监测、治疗。泼尼松是目前安全可靠的妊娠期治疗及预防SLE恶化、控制SLE活动的首选药物。SLE孕妇应加强孕期的监护，争取良好的妊娠结局。

Pregnancy Time and Affect of Pregnancy Outcome in Pregnancy Women with Systemic Lupus Erythematosus:A Clinical Analysis on 25 Cases

Objective To investigate the correlative factors that affect the outcome of pregnancy complicated with SLE and try to provide the best chance for conception and pregnant monitoring, to prevent the deterioration of SLE and improve the perinatal quality. Methods Retrospective analysis of 25 cases of pregnancy complicated with SLE. Results In 25 cases pregnancy complicated with SLE, 14 cases were in remission and well-controlled stage, 1 case premature labor, neonatal asphyxia 0 case, lupus nephritis 1 case, preeclampsia 0 case, 11 cases unstable, premature labor 4 cases, neonatal asphyxia 2 cases, lupus nephritis 3 cases, low serum platelet 3 cases, preeclampsia 2 cases. Conclusion The results show that first of all, the activity of SLE should be controlled and patients should get conception under the guidance of the obstetricians and physicians, Prednisone is one of the safe drugs for prevent women to control the activation of SLE and to prevent deterioration. Intensive monitors should be offered to prevent women complicated with SLE to acquire a better pregnancy outcome.