Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases |
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| Authors: | Irene Knuesel |
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| Affiliation: | Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland |
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| Abstract: | Reelin is a conserved extracellular glycoprotein crucial for neurodevelopment. In adulthood, Reelin is an important modulator of NMDA receptor-mediated neurotransmission, required for synaptic plasticity, learning and memory. Consequently, abnormal Reelin-mediated signaling has been associated with many human brain disorders involving directly or indirectly altered NMDA receptor function. For most neurological and neuropsychiatric disorders, abnormalities during brain development appear central in the disease etiology. However, a similar causative relationship for neurodegenerative diseases, like Alzheimer's disease (AD), has not been investigated yet. |
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| Keywords: | AD, Alzheimer's disease AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ApoE, apolipoprotein E APP, amyloid precursor protein CA, cornu ammonis (Ammon's horn) Cdk5, cyclin-dependent kinase 5 CNR, cadherin-related neuronal receptor CREB, cAMP-response element binding protein CRK/CRKL, V-crk sarcoma virus CT10 oncogene homolog (-like) Dab1, disabled-1 DG, dentate gyrus DISC1, disrupted-in-schizophrenia-1 GABA, gamma-aminobutyric acid GAD67, glutamic acid decarboxylase 67-kDa GAP-43, growth-associated protein-43 GSK3β, glycogen synthase kinase 3β IL, interleukin JNK, c-Jun N-terminal kinase JIP, JNK-interacting proteins LIM1K, LIM domain containing serine/threonine kinase 1 LIS1, lissencephaly 1 LTD, long-term depression LTP, long-term potentiation mTOR, mammalian target of rapamycin NMDA, N-methyl-d-aspartate PI3K, phosphatidylinositol-3-kinase PolyI:C, polyriboinosinic-polyribocytodilic acid PKB, phosphokinase B PSD, post-synaptic density SFK's, Src family of non-receptor tyrosine kinases TNFα, tumor necrosis factor alpha VGLUT1, vesicular glutamate transporter 1 VLDLR, very-low density lipoprotein receptor |
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