| 慢性乙型肝炎重症化的免疫学机制研究进展 |
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| 引用本文： | 郁嘉伦,张欣欣. 慢性乙型肝炎重症化的免疫学机制研究进展[J]. 国际流行病学传染病学杂志, 2009, 36(2). DOI: 10.3760/cma.j.issn.1673-4149.2009.02.015 |
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| 作者姓名： | 郁嘉伦 张欣欣 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院感染科,200025;上海交通大学医学院附属瑞金医院感染科,200025 |
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| 基金项目： | 卫生部艾滋病和病毒性肝炎等重大传染病防治重大专项基金 |
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| 摘 要： | 慢性乙型肝炎重症化的确切机制尚不清楚,目前认为HBV抗原所引起的宿主免疫应答是影响肝炎临床转归的决定性因素之一.现就最近几年研究较热的CTL、调节性/辅助性T细胞、枯否细胞、凋亡以及程序性死亡受体1等在慢性乙型肝炎重症化中的作用机制进行综述.
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| 关 键 词： | 肝炎病毒 乙型 慢性重型乙型肝炎 免疫应答 |
Recent advances in the research of immunologic pathogenesis in chronic severe hepatitis B |
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| YU Jia-lun,ZHANG Xin-xin. Recent advances in the research of immunologic pathogenesis in chronic severe hepatitis B[J]. International Journal of Epidemiology and Infectious Disease, 2009, 36(2). DOI: 10.3760/cma.j.issn.1673-4149.2009.02.015 |
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| Authors: | YU Jia-lun ZHANG Xin-xin |
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| Abstract: | The pathogenesis of the chronic severe hepatitis B(CSHB) is still unknown. At present, the immune response induced by specific antigenes of HBV is considered as one of the crucial faetors. This review concerns the latest research on CTL, Treg/helper T cell, Kupffer cells, apoptosis and programmed cell death 1 which may contribute to the CSHB. |
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| Keywords: | Hepatitis B virus Chronic severe hepatitis B Immune response |
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