| 罗匹尼罗中间体2-甲基3-硝基苯乙腈的合成 |
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| 引用本文： | 王松青,邓向阳,王绍杰,张为革. 罗匹尼罗中间体2-甲基3-硝基苯乙腈的合成[J]. 沈阳药科大学学报, 2000, 17(2): 103-104 |
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| 作者姓名： | 王松青 邓向阳 王绍杰 张为革 |
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| 作者单位： | 沈阳药科大学制药系,沈阳,110015 |
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| 摘 要： | 以邻二甲苯为原料 ,经硝化、氧化、水解、还原、氯化和氰代等 6步反应制得 2 甲基 3 硝基 苯乙睛 (8) ,对其中还原、氯化和氰代等反应操作进行了改进 ,使用三氯化磷代替三溴化磷 ,结果较好 ,该法未见文献报道 .
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| 关 键 词： | 帕金森症 药物治疗 多巴胺 D2受体激动剂 合成 |
Synthesis of 2-Methyl-3-nitrobenzyl Cyanide,an Important Intermediate of Ropinirol Synthesis |
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| Wang Songqing,Deng Xiangyang,Wang Shaojie,Zhang Weige. Synthesis of 2-Methyl-3-nitrobenzyl Cyanide,an Important Intermediate of Ropinirol Synthesis[J]. Journal of Shenyang Pharmaceutical University, 2000, 17(2): 103-104 |
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| Authors: | Wang Songqing Deng Xiangyang Wang Shaojie Zhang Weige |
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| Abstract: | Methyl-3-nitrobenzyl cyanide was prepared from o-xylene by nitration, oxidation, hydrolysis,reduction,chloration and cyanation.The halogation was improved by using phosphous trichloride to replace phosphous tribromide and good results were obtained. |
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| Keywords: | Parkinson′s disease drug therapies dopamine D_2 receptor agonist synthesis |
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