家兔严重体表烧伤肺的病理变化

66只家兔分为对照组(n=6)和致伤组,致伤组从伤后2h至30d分为10个时相点(每时相n=6)。经LM、TEM、SEM观察气管和肺,伤后6h开始出现各种病变,气管和支气管见充血,水肿,中性粒细胞浸润,纤毛断裂、脱落、倒伏、粘着,杯状细胞和Clara细胞增多。肺间质水冲,中性粒细胞浸润或聚集于毛细血管内,Ⅱ型肺泡上应及其板层体减少,板层体空泡化等改变,3d时病变最重,7d之后各项病变逐渐减少或减轻。讨论了主要病变的发生及其意义。

Pathological Changes of the Lungs in Severe Burns in Rabbits

Sixty-six rabbits were divided into 2 groups, the control group and the experimental group. The latter was subdivided into 10 groups according to the time of observation after burn injury including 2nd-hour group to 30th-day group. Each group consisted of 6 animals. Specimens from the trachea and the lungs were examined with optical microscopy, scanning electron microscopy and transmission electron microscopy.No obvious lesion was seen in the specimens from the control. In the experimental group, various pathological changes began to appear from the 6th hour after injury. In the trachea and bronchi, congestion of varying degrees, edema, leucocytic infiltration, lodging, adhesion, breaking or separation of cilia, and increase of goblet cells and Clara cells in number weie found. In. the lungs, interstitial edema of varying degrees, accumulation and infiltration of neutro-phils in capillaries, pulmonary interstitium and alveolar spaces, decrease in num ber of type II pneumocytes and their lamellar bodies, vacuolization of lamellar bodies, and phagocytosis of lamellar bodies by macrophages were seen. Most prominent changes were shown on the 3rd day postburn, and they began to alleviate on the 7th day. The number of type II pneumocytes and their lamellar bodies gradually increased number. Some lesions still existed on the 30th day postburn but no significant fibrosis could be found. The occurrence and development of the main lesions and their significance were discussed.