| Adr型HBV全基因转基因小鼠DC和T细胞功能的研究 |
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| 引用本文： | 邵启祥,王文红,许化溪,傅翠梅,李良菊,沈关心,刘恭植. Adr型HBV全基因转基因小鼠DC和T细胞功能的研究[J]. 江苏大学学报(医学版), 2000, 0(2) |
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| 作者姓名： | 邵启祥 王文红 许化溪 傅翠梅 李良菊 沈关心 刘恭植 |
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| 作者单位： | 镇江医学院免疫学研究室!江苏镇江212001(邵启祥，王文红，许化溪，傅翠梅，李良菊)，同济医科大学免疫学教研室!湖北武汉430000(沈关心)，镇江医学院免疫学研究室!江(刘恭植) |
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| 基金项目： | 江苏省科委应用基础资助!(BJ990 4 1 )，江苏省教委资助!(98KJD31 0 0 4 # ) |
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| 摘 要： | 目的方法 :通过对分离Adr型HBV全基因转基因小鼠的脾脏淋巴细胞和树突状细胞 ,并研究其对ConA ,HBeAg ,ConA HBeAg刺激的应答能力。结果 :发现HBV转基因小鼠对ConA的应答基本正常 ,但对HBeAg ,ConA HBeAg的应答明显低于对照组 ,说明HBV转基因小鼠DC和T细胞对HBV存在特异性的免疫耐受。
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| 关 键 词： | HBV 转基因小鼠 HBeAg DCT细胞免疫耐受 |
Study for the Functions of T Cell and DCs in the Adr Type HBV Transgenic Mouse |
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| SHAO Qi xiang,WANG Wen hong,XU Hua xi,et al. Study for the Functions of T Cell and DCs in the Adr Type HBV Transgenic Mouse[J]. Journal of Jiangsu University Medicine Edition, 2000, 0(2) |
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| Authors: | SHAO Qi xiang WANG Wen hong XU Hua xi et al |
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| Abstract: | Objective: To investigate the function of dendritic cell and T lymphocytes of the Adr type hepatitis B Virus (HBV) transgenic mice. Methods: Isolating the dendritic cells and lymphocytes from spleen of hepatitis B Virus (HBV) transgenic mice, and study the responsing level after stimulating with the ConA, HBeAg, ConA HBeAg respectively. Results: The responsing function of the dendritic cells and T lymphocytes of hepatitis B Virus (HBV) transgenic mice is normal when it stimulated by ConA, but its function is lower when it stimulated by HBeAg, ConA HBeAg. Conclusions: The dendritic cells and T lymphocytes may tolerate to the HBV in the hepatitis B Virus (HBV) transgenic mice. |
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| Keywords: | HBV Transgenic mouse HBeAg DC T cell Immune tolerance |
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