唑来膦酸联合放射治疗42例骨转移性癌的临床观察

目的观察唑来膦酸联合放射治疗骨转移性癌的疗效及毒副作用。方法 42例确诊的骨转移性癌随机分为治疗组22例（放疗＋唑来膦酸）和对照组20例（单纯的放疗）。观察治疗前后疼痛的缓解、活动能力改善及副作用。结果治疗结束时两组疼痛缓解率没有统计学差异（86.4%vs 80%,P〉0.05）,但治疗结束后3月开始,两组疼痛缓解率有统计学差异（81%vs 50%,P〈0.05）。结论唑来膦酸联合放射治疗骨转移性癌的疗效优于单纯放疗,疼痛缓解持续时间更长,毒副作用能耐受。

Effect of the combination of zoledronic acid and radiotherapy on treatment of patients with bone metastasis

Objective To observe the efficacy and adverse effect of the combination of zoledronic acid and radiotherapy in treatment of patients with bone metastasis.Methods 42 histological and cytological confirmed bone metastasis patients were randomly assigned to therapeutic group and control group,which were treated with zoledronic acid combined with radiotherapy and radiotherapy alone,respectively.Results There were no significant difference between the two groups for reducing the pain at the finish time of treatment（86.4% vs 80%,P〈0.05）.However,there were significant differences for reducing pain and ECOG PS improving between the two groups 3 months after treatment（81% vs 50%,P〉0.05）.Conclusion The combination of zoledronic acid with radiotherapy was superior radiotherapy alone for patients with bone metastasis and the release time was longer,the adverse effects were tolerable.