| 奥氮平与MECT治疗精神分裂症急性期攻击激越的对照研究 |
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| 引用本文： | 沈婷,王飚,李朝,王慧芳,王晓良,韩慧琴. 奥氮平与MECT治疗精神分裂症急性期攻击激越的对照研究[J]. 四川精神卫生, 2011, 24(2): 89-91 |
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| 作者姓名： | 沈婷 王飚 李朝 王慧芳 王晓良 韩慧琴 |
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| 作者单位： | 上海交通大学医学院附属精神卫生中心,200030 |
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| 摘 要： | 目的探讨奥氮平与改良电抽搐（modified ECT,MECT）治疗首次发作的精神分裂症患者急性期的疗效及安全性。方法前瞻性、开放性、随机对照设计,90例首次急性发作的精神分裂症患者随机分为三组：即奥氮平组,依托咪酯MECT组与丙泊酚MECT组,每组30例。奥氮平初始剂量为5mg/d,最大20mg/d;依托咪酯MECT组和丙泊酚MECT组分别为0.21~0.3mg/kg与1.82-2.44mg/kg诱导麻醉,MECT治疗隔日一次,两周共6次。治疗观察时间两周,治疗第1天及第14天以阳性与阴性症状量表（PANSS）的兴奋因子（EC）评定疗效。结果治疗两周后三组的PANSS-EC因子评分均显著下降,奥氮平组为（10.23±3.17）,依托咪酯MECT组为（9.04±2.48）,丙泊酚MECT组为（7.66±3.43）,三组之间差异无统计学意义（P〉0.05）。三组不良反应差异亦无统计学意义（P〉0.05）。结论奥氮平治疗精神分裂症急性期攻击激越症状的疗效,与依托咪酯或丙泊酚诱导的MECT相当。奥氮平是精神分裂症急性期攻击激越症状的有效治疗选择之一。
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| 关 键 词： | 精神分裂症 奥氮平 改良电休克 依托咪酯 丙泊酚 |
The effective study of olanzapine and MECT in acute schizophrenia patients |
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| SHEN Ting,WANNG Biao,LI Chao,et al.. The effective study of olanzapine and MECT in acute schizophrenia patients[J]. Sichuan Mental Health, 2011, 24(2): 89-91 |
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| Authors: | SHEN Ting WANNG Biao LI Chao et al. |
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| Affiliation: | SHEN Ting,WANNG Biao,LI Chao,et al.Shanghai Mental Health Center,School of Medicine Shanghai Jiaotong University,Shanghai 200030,China |
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| Abstract: | Objective To explore the effects and safety of olanzapine in the treatment of schizophrenia patients with agitate symptoms in the acute phrase comparing with MECT by etomidate and propofol.Methods 90 schizophrenia patients were distributed into three groups in random.Group A were treated with olanzapine in a regimen of 5~20 mg/d during two weeks.Group B administered etomidate(0.21~0.3mg/kg),group C underwent general anaesthesia with propofol(1.82~2.44mg/kg)during MECT,once per 2 days and total 6 times in tw... |
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| Keywords: | Schizophrenia Olanzapine MECT Etomidate Propofol |
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