| Langerhans细胞与胆脂瘤型中耳炎 |
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| 引用本文： | 刘立中,李哲生,胡牧,唐军民,胡艳玲,唐岩.Langerhans细胞与胆脂瘤型中耳炎[J].中华耳鼻咽喉头颈外科杂志,1995(1). |
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| 作者姓名： | 刘立中 李哲生 胡牧 唐军民 胡艳玲 唐岩 |
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| 作者单位： | 新疆医学院第一附属医院耳鼻咽喉科，北京医科大学第三临床医学院耳鼻咽喉科 |
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| 基金项目： | 美国中华医学会基金奖学金 |
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| 摘 要： | 应用ＡＴＰ酶组织化学、免疫组织化学和超微结构等研究手段，观察胆脂瘤表皮铺片及冰冻切片中Ｌａｎｇｅｒｈａｎ细胞（ＬＣ），以及Ｔ＿４、Ｔ＿８、Ｂ细胞和ＨＬＡ－ＤＲ阳性细胞的形态、分布，并通过形态学计量和图象分析得出，胆脂瘤表皮中ＬＣ密度与外耳道皮肤表皮中ＬＣ密度差异无显著性。胆脂瘤基质中Ｔ＿４，平均面数密度和Ｔ＿４／Ｔ＿８比值高于正常人外周Ｔ＿４／Ｔ＿８之比，通过细胞与细胞间相互作用，ＬＣ可能在中耳胆脂瘤发生中起到一定作用。
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| 关 键 词： | Langerhans细胞 胆脂瘤 中耳炎 |
Langerhans Cells and Human Aural Cholesteatoma |
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| Liu Lizhong, LiZhesheng, HuMu,et al.Langerhans Cells and Human Aural Cholesteatoma[J].Chinese JOurnal of Otorhinolaryngology Head and Neck Surgery,1995(1). |
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| Authors: | Liu Lizhong LiZhesheng HuMu |
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| Abstract: | Enzyme histocbemical , immunohistochemical and ultramicroscopic analysis of 20 human aural cholesteatoma matrices revealed the presence of Langerhans cells,T lymphocytes,B lymphocytes and HLA-DR positive cells. There was no significant difference of the numerical density on the area of Langerhans cells between the cholesteatoma matrices and the normal ear canal skin. The numerical den-sity on the area of T_4 and the ratio of T_4/T_8 of cholesteatoma were higher than those of the normal ear canal skin. Through cell-to-cell interaction, Langerhans cells probably play a key role in skin-related disorders, including cholesteatoma. |
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| Keywords: | Langerhans cells Cholesteatoma Otitis media |
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