| 人脊柱裂胚胎脑干组织的全基因组表达谱 |
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| 引用本文： | 赵虹,Li Xiang,Li Wan-I,He Quanren,Zhang Ting,Zheng Xiaoying,Zhou Ran,解军. 人脊柱裂胚胎脑干组织的全基因组表达谱[J]. 中国神经再生研究, 2011, 6(5): 366-372 |
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| 作者姓名： | 赵虹 Li Xiang Li Wan-I He Quanren Zhang Ting Zheng Xiaoying Zhou Ran 解军 |
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| 作者单位： | Shanxi Medical University,Department of Biochemistry and Molecular Biology, Ministry of Education Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,Department of Physiology and Pharmacology, University of Georgia, Georgia 361004, USA,Department of Physiology and Pharmacology, University of Georgia, Georgia 361004, USA,Capital Institute of Pediatrics, Beijing 100020, China,Institute of Population Research, Peking University, Beijing 100732, China,Shanxi Traditional Medical College, Taiyuan 030024, Shanxi Province, China,山西医科大学 |
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| 基金项目： | National Key Project of Scientific and Technical Supporting Programs funded by the Ministry of Science & Technology of China (No. 2007BA107A02), National Basic Research Program of China (973 Program): 2007CB511902, the Shanxi scholarship council of China (No.2008-48), and Shanxi Natural Science Foundation (2010011049-2). |
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| 摘 要： | 背景 神经管畸形的发病机理至今尚未阐明，较为公认的观点是由环境与遗传因素共同作用的结果。我们的研究旨在明确人脊柱裂胚胎的基因表达谱变化。方法 3例17周人脊柱裂胚胎经确诊后引产将其脑干组织提取总RNA，应用全基因组表达芯片Affymetrix HG-U133A 2.0 检测，对比正常对照组，将芯片结果数据做差异表达分析。 结果 差异表达基因为14500条，其中182条为显著差异，140条显著上调，42条显著下调。根据基因的生物学功能将其分类于19条通路，约50％的基因属于细胞凋亡，生长，粘附和细胞周期，应激，DNA复制和修复，信号传导，神经系统（NS）发育，氧化还原，免疫反应，基因转录调控通路。结论 人脊柱裂胚胎17周脑干的基因表达呈现出多生物学通路的差异改变。
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| 关 键 词： | 脊柱裂，基因表达，凋亡，神经管畸形 |
Brain stem global gene expression profiles in human spina bifida embryos |
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| Zhao Hong,Li Xiang,Li Wan-I,He Quanren,Zhang Ting,Zheng Xiaoying,Zhou Ran and Xie Jun. Brain stem global gene expression profiles in human spina bifida embryos[J]. Neural Regeneration Research, 2011, 6(5): 366-372 |
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| Authors: | Zhao Hong Li Xiang Li Wan-I He Quanren Zhang Ting Zheng Xiaoying Zhou Ran Xie Jun |
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| Affiliation: | Department of Biochemistry and Molecular Biology, Ministry of Education Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,Department of Biochemistry and Molecular Biology, Ministry of Education Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,Department of Physiology and Pharmacology, University of Georgia, Georgia 361004, USA,Department of Physiology and Pharmacology, University of Georgia, Georgia 361004, USA,Capital Institute of Pediatrics, Beijing 100020, China,Institute of Population Research, Peking University, Beijing 100732, China,Shanxi Traditional Medical College, Taiyuan 030024, Shanxi Province, China,Department of Biochemistry and Molecular Biology, Ministry of Education Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China |
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| Abstract: | |
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| Keywords: | apoptosis GeneChip gene expression neural tube defect spina bifida |
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