Net growth delay: a novel parameter derived from tumor growth curves |
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| Authors: | H P Beck-Bornholdt F Würschmidt H Vogler |
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| Affiliation: | 1. Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow 226 031, India;2. Department of Biology, University of Alabama at Birmingham, AL 35294, USA;3. Academy of Scientific and Innovative Research (AcSIR), New Delhi, India;1. Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States;2. Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States;3. M.D. Program, Baylor College of Medicine, Houston, TX, United States;4. VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States |
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| Abstract: | Growth delay does not only reflect the effect of treatment on the tumor parenchymal cells but also on the stroma. Due to tumor bed effect, the extent of growth delay determined from tumor growth curves is highly dependent on the end volume chosen. It was aimed to minimize the influence of the tumor bed effect on the growth delay calculated by choosing a smaller size and essentially an earlier time for regrowth. Net growth delay is a novel parameter derived from the tumor growth curves, allowing a better comparison of the results with colony assay and tumor control data. |
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