The 5-HT1A receptor antagonist (S)-UH-301 blocks the (R)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat |
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Authors: | L Arborelius B Backlund Höök U Hacksell T H Svensson |
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Institution: | (1) Present address: Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, S-17177 Stockholm;(2) Department of Organic Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden |
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Abstract: | Summary (S)-UH-301 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin, 0.5–4.0 mg/kg i.V.] did not significantly alter the firing rate of 5-hydroxytryptamine (5-HT) containing neurons in the dorsal raphe nucleus (DRN) as a group, although some individual cells were activated whereas others were depressed. However, (S)-UH-301 (2.0mg/kg i.v.) consistently reversed the inhibition of DRN-5-HT cells produced by the selective 5-HT1A receptor agonist (R)-8-OH-DPAT (0.5 g/kg i.v.) and the dose-response curve for this effect of (R)-8-OH-DPAT was markedly shifted to the right by pretreatment with (S)-UH-301 (1.0mg/kg i.v.). These results support the notion that (S)-UH-301 acts as an antagonist at central 5-HT1A receptors. |
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Keywords: | 5-HT1A 8-OH-DPAT (S)-UH-301 5-HT1A receptor antagonist electrophysiology dorsal raphe nucleus |
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