Synthesis and bioactivities of 2-oxo-naphtho (1,2-d)thiazolo(3,2-a)pyrimidine derivatives]

Synthesis and Bioactivities of Some Derivatives of Naphthol 1,2-d]thiazolo 3,2-a]pyrimidin-2-one For the investigation of structure-activity relationships, the title compounds 5a-d were synthesized. Together with the intermediate 2 they were tested on rats for their antihypertensive effect, in a mouse screening for CNS responses and on the isolated ileum of the guinea pig for their anticholinergic and antihistaminic activities.