Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy |
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Authors: | Belgin Kü ü kkaya, Rezzan Aker, Meral Yü ksel, Filiz Onat,A. Sü ha Yal in |
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Affiliation: | Belgin Küçükkaya, Rezzan Aker, Meral Yüksel, Filiz Onat,A. Süha Yalçin, |
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Abstract: | We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol- and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus). In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation. |
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Keywords: | Chemiluminescence MK-801 Iron-induced epilepsy Oxidative changes |
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