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| 番茄红素对S_(180)荷瘤小鼠抗肿瘤作用的实验研究 | |
| 引用本文： | 潘洪志,姜秀梅,万丽葵,那立欣,王军.番茄红素对S_(180)荷瘤小鼠抗肿瘤作用的实验研究[J].卫生研究,2004,33(4):456-457. |
| 作者姓名： | 潘洪志 姜秀梅 万丽葵 那立欣 王军 |
| 作者单位： | 1. 哈尔滨医科大学公共卫生学院,哈尔滨,150001 2. 北华大学医学院预防系 3. 黑龙江省疾病控制中心 |
| 摘 要： | 目的 研究番茄红素 (LP)的体内抗肿瘤作用。方法 通过S1 80 肉瘤建立荷瘤小鼠模型 ,给予番茄红素后观察荷瘤小鼠肿瘤生长情况及对小鼠免疫系统和抗氧化酶的影响。结果 给药后能够增强脾脏淋巴细胞增殖能力 ,提高自然杀伤细胞 (NK)活性 ,可升高小鼠血清SOD、GSH Px活性 ,降低MDA含量 (P <0 0 5 )。结论 番茄红素具有明显的抗肿瘤作用 ,其作用可能是通过提高免疫系统功能和机体的抗氧化酶活力来实现的。 |
| 关 键 词： | 番茄红素 肿瘤 S180 小鼠 |
| 文章编号： | 1000-8020(2004)04-0456-02 |
| 修稿时间： | 2003年9月27日 |
Experimental studies of lycopene in inhibiting tumor growth in S180-bearing mice |
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| Pan Hongzhi,Jiang Xiumei,Wan Likui,Na Lixin,et al..Experimental studies of lycopene in inhibiting tumor growth in S180-bearing mice[J].Journal of Hygiene Research,2004,33(4):456-457. | |
| Authors: | Pan Hongzhi Jiang Xiumei Wan Likui Na Lixin |
| Institution: | Public Health School of Harbin Medical University, Harbin 150001, China. |
| Abstract: | Objective To observe the effect of lycopene(LP) on tumor in mice. Methods S 180 bearing mice were used as animal model.The mice were given LP by oral. The effects of LP on tumor weight, immune function and antioxidative enzyme were measured respectively. Results LP group could promote spleen lymphocyte proliferation, NK activity and increase activity of SOD , GSH Px and decreased the concentrations of MDA significantly compared with model group( P <0 05). Conclusion LP could inhibit the growth of S 180 tumor. The antitumor effect may be related to its immune function and antioxidative effect. |
| Keywords: | lycopene tumor S 180 mice |
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