E-cadherin,CD44变异体6在子宫腺肌病发病机制的研究

目的检测与分析上皮细胞钙粘蛋白（上皮钙粘附素，E—cadherin），CD44变异体6（CD44 varient 6，CD44 v6）在子宫腺肌病（adenomyosis，AM）在位内膜及异位内膜细胞中的表达情况及相关性，探讨其在AM发病中的作用。方法采用免疫组化Envision法检测正常子宫内膜，AM的在位内膜、异位内膜组织中E—cadherin，CD44v6的表达，采用SPSS13．0统计软件对实验数据进行统计学分析。结果E—cadherin在AM在位内膜和异位内膜的表达，较正常子宫内膜弱。差异有显著意义（P〈0．05）；CD44 v6在AM在位内膜和异位内膜的表达，较正常子宫内膜强，差异有显著意义（P〈0．05）。AM异位内膜和在位内膜中，E—cadherin和CD44 v6的表达，呈负相关（P〈0．05）；正常内膜中，Ecadherin和CD44 v6的表达无明显相关性（P〉0．05）。结论E—cadherin，CD44 v6在AM在位内膜及异位内膜细胞中表达异常，提示其可能在AM的发生发展中起重要作用；E—cadherin，CD44 v6在AM在位内膜及异位内膜细胞中表达有相关性，提示二者在AM的发生发展中有协同作用。

The study of E-cadherin and CD44 varient 6 on pathogenesis in human adenomyosis

Objective To observe the expression of E-cadherin and CD_(44) v6 in human adenomyosis.To explore the correlation between the expression of E-cadherin and CD_(44)v6 in the pathogenesis of adenomyosis. Methods The expression of E-cadherin and CD_ 44 v6 in 50 ectopic and eutopic endometrium of adenomyosis was detected by immunohistochemical method in comparison with 30 normal endometrium. Results were analyzed by SPSS13.0 statistical software. Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium (P<0.05). The expression of CD_(44)v6 in ectopic and eutopic endometrium of adenomyosis is higher than that in normal endometrium(P<0.05). There was a negative correlation between the expression of E-cadherin and CD_(44) v6 in eutopic endometrium of adenomyosis and ectopic endometrium of adenomyosis (P<0.05). There was no correlation between the expression of E-cadherin and CD_(44)v6 in normal endometrium (P>0.05). Conclusion The abnormal expression of E-cadherin and CD_(44)v6 in eutopic endometrium and ectopic endometrium has relationship with the etiology of adenomyosis.