CD24在乳腺癌组织中表达的意义及其与Ki67、Bcl-2的关系

目的 研究乳腺浸润性导管癌组织中CD24的表达及与细胞核增殖抗Ki67及凋亡抑制蛋白Bcl-2的关系,探讨CD24在乳腺癌发生发展中的作用.方法 应用免疫组化ElivisiDnTM Plus二步法检测86例乳腺浸润性导管癌组织和30例非瘤乳腺上皮组织中CD24及Ki67、Bcl-2的表达情况,分析CD24表达与Ki67、Bcl-2以及患者年龄、肿瘤大小、组织病理学分级、淋巴结转移、临床分期等临床病理学参数之间的关系.结果 在86例乳腺浸润性导管癌中CD24表达的阳性率为87.2%(75/86),与对照组比较均有统计学差异(P<0.01);CD24表达与患者年龄、肿瘤大小、组织病理学分级、临床分期未见显著相关(P0.05),与腋窝淋巴结转移呈正相关(P<0.01);乳腺癌CD24表达与Ki67表达呈正相关(P<0.01),与Bel-2表达没有相关性(P0.05).结论 CIY24蛋白的表达与乳腺癌细胞增殖及侵袭转移具有相关性,是判断肿瘤生物学行为和患者预后的重要参考指标之一.

Correlation between CD24 expression and its relation with Ki67,Bcl-2 in breast carcinoma

Objective To investigate the expression of CD24 and Ki67 in the invasive breast ductal car-cinoma tissues, so as to assess the role of CD24 protein in the carcinogenesis and progression of breast canc-er. Methods The expression of CD24 and Ki67, Bcl-2 was examined by immunohistochemically in 86 breast cancer specimens and 30 non-cancer specimens ( ElivisionTM Plus). The relationship between CD24 expression and Ki67, Bcl-2, patient age, tumor size, histopathologic grade, axillary lymphnode metastasis, and clinical stage of breast cancer was analyzed. Results In 86 eases of invasive breast ductal carcinoma, the positive incidences of CD24 was 87.2% (75/86), which distinguished apparently from those of the con-trol group( P <0.01 ). In breast carcinoma tissues, the expression of CD24 was positively related to axillary lymphnode metastasis(P <0.01 ), but was not related to patients age,tumor size, histopathologic grade and clinical stage(P>0.05). CD24 expression was positively related to Ki67 (P<0.01 ) and negatively relat-ed to Bcl-2(P>0.05). Conclusion CD24 expression was related to the proliferation, invasion and me-tastasis of breast cancer cells and it can serve as an important marker for predicting biological behavior and prognosis of tumors.