HBsAg阴性血液传播乙型肝炎危险性的探讨

559名HBsAg阴性的健康人抗-HBc和抗-HBs均阳性者检出率为31.31%(175/559),单项抗-HBc阳性检出率为26.83%(150/559)。随机抽取单项抗-HBc阳性,以及抗-HBs和抗-HBc均阳性血标本各150份,应用斑点分子杂交技术,HBVDNA的检出率分别为5.33%和2.0%;高滴度单项抗-HBc阳性血HBVDNA检出率(12.0%)高于低滴度单项抗-HBc阳性血的HBVDNA检出率(4.0%)。结果表明,HBsAg阴性血液仍具有传播HBV的危险性;抗-HBs和抗-HBc均阳性的血液并非绝对安全;高滴度单项抗-HBc阳性血液传播HBV的危险性更大。建议对献血者加测抗-HBc。

TREATMENT OF HEPATITIS B TRANSMITTING RISK OF HBsAGNEGATIVE BLOOD

Of 559 HBsAg-negative healthy patients,the positive rate of testing for antibody to both HBc and HBs was 31.31% (176/559),and the po- sitive rate of testing for antibody only to HBc was 26.83% (150/559).Of 150 random-sampled blood specimens with positive antibody only to HBc and 150 random-sampled blood specimens with positive antibody to both HBs and HBc,the positive rates of testing for HBVDNA,using the dot hybridi- zation technique,were 5.33% and 2.0% respectively.The positive rate of testing for HBVDAN in high titer blood with positive antibody only to HBc was higher(12.0%) than that (4.0%) in low titer blood with posi- tive antibody only to HBc.The results of testing showed that the HBsAg- negative blood could still take the risk of transmitting HBV,the blood with positive antibody to both HBs and HBc was not absolutely safe,the HBV- transmitting risk of high titer blood with positive antibody only to HBc was even higher.Additional testing the donors for antibody to HBc should be recommended.