雌激素与女性认知功能关系的研究进展

随着女性平均预期寿命的延长及阿尔茨海默病(alzheimer disease,AD)的发病率明显上升,雌激素与女性认知功能的关系研究成为当今学术界研究的热点之一。细胞培养和动物实验数据已经证实,雌激素能通过多种途径保护认知功能相关区域的神经细胞,进而提高认知功能。但是学者们对雌激素水平和女性认知功能的相关性问题,及激素补充治疗(HRT)对围绝经期及绝经后女性认知功能是否有保护作用仍有争议。多数研究表明雌激素水平和女性认知功能是相关的,但是不同的人群,不同时期,不同的认知测试可能会有不同结果。激素补充治疗能否提高女性认知功能取决于研究人群、治疗时机、药物种类及个体化用药等。

Research progress of relationship between estrogen and cognition in women

As the increasing of women's life expectancy and the rising of the incidence rate of Alzheimer disease (AD),the study on the relationship between estrogen and cognition in women becomes one of the pop topics in today's academia.Several cell culture and animal studies have suggested that estrogen can have protective effects on the neurons in cognition-related brain areas to influence cognitive function,but studies of the association between levels of estrogen and cognitive function in women,as well as the effects of hormone replacement therapy (HRT) given to perimenopausal and postmenopausal women,have produced inconsistent and complex results.However,most of the studies have recently found that levels of estrogen are associated with cognitive function in women,but the results may vary in different subjects,periods and using different cognitive tests.HRT can improve cognitive function in women or not may depend on the study population,treatment opportunity,the type of drugs,individualized medication and so on.