| CyclinD1表达与泌尿系统肿瘤关系的研究进展 |
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| 引用本文： | 牛德方,崔岩(综述),陈辉(审校). CyclinD1表达与泌尿系统肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2016, 0(6): 547-550. DOI: 10.11904/j.issn.1002-3070.2016.03.014 |
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| 作者姓名： | 牛德方 崔岩(综述) 陈辉(审校) |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院泌尿外科 哈尔滨 150081 |
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| 基金项目： | 1．黑龙江省卫生计生委科研课题(2016－114)；2．2016年度哈尔滨医科大学创新科学研究资助项目 |
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| 摘 要： | D型细胞周期蛋白（Cyclin）是目前已知的细胞周期蛋白（Cyclins）中的亚型之一，与肿瘤的关系最为密切，D型Cyclin中的CyclinD1是细胞周期中起关键作用的正向调节因子，主要作用于细胞增殖及细胞分裂过程，CyclinD1特异性过表达于多种肿瘤细胞。研究发现，在泌尿系恶性肿瘤中也存在Cy-clinD1过表达现象，且与肿瘤细胞的侵袭、转移和复发有关。因此，以CyclinD1作为泌尿系肿瘤的研究靶点，有可能为泌尿系恶性肿瘤的预防及治疗等提供新的思路。
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| 关 键 词： | CyclinD1 尿路上皮癌 肾癌 前列腺癌 阴茎癌 |
Progress in the research of CyclinD1 in urinary tumor |
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| Abstract: | Cyclin D is the most closely relationship with tumor ,and it is currently known one of the sub-types of cyclins.CyclinD1,as a positive regulatory factor ,has an important role in the process of cell cycle ,espe-cially in cell proliferation and division .CyclinD1 is unusually up-regulated in lots of human cancers .CyclinD1 is a recently discovered protein which is highly expressed in the urinary tumors ,and its expression in tumors is asso-ciated with a more aggressive phenotype ,prognosis and recurrence .Therefore,the research of the target point to CyclinD1 in the urinary tumors may provide a new method for the therapy to urinary tumors . |
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| Keywords: | CyclinD1 Urothelial carcinoma Renal carcinoma Prostatic carcinoma Penile carcinoma |
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