白癜风神经内分泌免疫发病机制研究新进展

目的白癜风是一种常见的获得性色素脱失性疾病,临床以皮肤黏膜出现边界清楚的瓷白色白斑为主要特征。尽管白癜风相关的研究取得了长足的进展,但白癜风发病具体机制仍未完全阐明。研究表明,白癜风与遗传、氧化应激、免疫等多种因素密切相关,但其具体的作用机制仍需进一步研究。近期,关于神经免疫系统相互作用导致免疫紊乱的致病机制逐渐受到重视。在心身应激等情况下,皮肤外周神经末梢神经肽的异常释放可以导致皮肤免疫微环境的紊乱,进一步损伤黑素细胞。神经肽参与白癜风发生发展的相关研究越来越多,基于神经肽调节的思路也为白癜风的治疗开辟了新的方向。

The neuro-endocrine-immune pathogenesis of vitiligo

Vitiligo is an acquired depigmentary skin disorder characterized by well-demarcated, white macules. Despite relevant new research and progresses, why and how melanocytes disappear is not fully understood. In spite of recent ifndings implicated the disease is closely related to many factors, such as genetic, immune and oxidative stress factors, the exact pathogenesis of vitiligo remains obscure. An innovative concept based on a functional crosstalk between the nervous and immune system is emerging. Neuropeptides released from peripheral nerve endings could synergize new cytokines to disturb the immune microenvironment of skin. Evidence is increasing regarding the role of neuropeptides in the pathogenesis of vitiligo and a new winning approach of vitiligo therapy based on neuropeptides regulation is at the horizon.