Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients |
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| Authors: | Doherty T Mark Demissie Abebech Olobo Joseph Wolday Dawit Britton Sven Eguale Tewodros Ravn Pernille Andersen Peter |
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| Affiliation: | Department of Tuberculosis Immunology, Statens Serum Institute. Hvidovre Hospital, Copenhagen, Denmark. TMD@ssi.dk |
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| Abstract: | Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period. |
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