米非司酮两种方案联合甲氨蝶呤治疗异位妊娠效果比较

比较米非司酮两种服用方法联合甲氨蝶呤（MTX）治疗异位妊娠的临床疗效。150例输卵管妊娠患者分层随机分为200mg顿服组（77例）和150mg分服组（73例）。结果显示，Fernandez评分≤12分时，200mg顿服组和150mg分服组治疗成功率差异无统计学意义（98％比100％，P〉0．05），〉12分时则两组差异有统计学意义（10／13，3／11，p〈0．05）。两组胃肠道不良反应发生率差异有统计学意义（P〈0．05），但WBC下降例数、hCG降为正常时间及平均住院日差异无统计学意义（P〉0．05）。

Treatment of ectopic pregnancy by two dosages of mifepristoned plus methotrexate

The clinical efficacy of two dosages of mifepristone plus methotrexate （ MTX ） in the treatment of ectopic pregnancy was compared. One hundred and fifty patients with ectopic pregnancy patients were stratified randomly into 200 mg＇s single oral group （n =77） and 150 mg graded oral group （n = 73 ）. The results showed that, when the Fernandez scores ≤ 12 points, the difference of treatment success rate was not statistically significant （98% vs 100% , P 〉 0.05 ） ; and when 〉 12 points, two groups had statistical significance difference （10/13, 3/11, P 〈 0. 05）. The incidence of gastrointestinal adverse reactions was statistically significant between two groups （ P 〈 0. 05 ）. However, the number of leucopenia, the time of hCG back to normal and average length of hospital stay were not statistically different（ P 〉 0. 05 ）.