糖耐量减低患者胰岛素抵抗与血脂的相关性研究

分析220例2型糖尿病患者的一级亲属中糖耐量减低（IGT）者胰岛素抵抗（IR）对血脂的影响，并与正常糖耐量（NGT）组相比较。结果，IGT组（120例）血清TG、TC、LDL—C水平较NGT组升高，HDL—C降低，且稳态模型胰岛素抵抗指数（HOMA—IR）、胰岛素曲线下面积（胰岛素AUC）也升高（均P〈0．05）；IGT患者血清TG水平与HOMA—IR及胰岛素AUC正相关，HDL—C与HOMA—IR负相关（P〈0．05）。因此，IGT患者已存在血脂异常，且和IR密切相关。

Correlation of blood lipids and insulin resistance in patients with impaired glucose tolerance

Blood lipid level and its associations with insulin resistance were studied in patients with impaired glucose tolerance （IGT）. Two hundred and twenty first degree relatives of type 2 diabetes mellitus were grouped into normal glucose tolerance （ NGT ） and IGT groups according to results of oral glucose tolerance test. Compared with the NGT group, the IGT patients had higher serum levels of total triglyeeride （ TG）, total cholesterol （ TC ）, low density lipoprotein-C （ LDL-C ） but a lower serum level of high density lipoprotein-C （HDL-C）. Homeostasis model of assessment for insulin resistance index （HOMA-IR） and area under curve of insulin （AUCI） also increased. A positive relationship was found between TG and HOMA-IR （or AUCI）, but a negative relationship existed between HDL-C and HOMA-IR. In conclusion, abnormal blood lipid metabolism is present in IGT patients and it has a close correlation with insulin resistance.