妊娠期肝内胆汁淤积症患者胆汁酸水平与围产儿预后关系的研究

131例妊娠肝内胆汁淤积症（ICP）孕妇根据胆汁酸水平分为轻度及重度ICP组，100例同期正常孕妇为对照组，分析各组孕妇的病历资料和围产儿预后情况。ICP孕妇血清胆汁酸、肝酶、血脂的水平显著高于对照组孕妇，差异有统计学意义（P〈0．01）。ICP孕妇围产儿预后显著差于对照组孕妇，差异具有统计学意义（P〈0．05）。ICP孕妇高胆汁酸水平对围产儿预后可产生严重不良影响。

Relationship between serum total bile acid and fetal prognosis in patients with intrahepatic cholestasis of pregnancy

To explore the relationship between serum total bile acid concentration and fetal prognosis in patients with intrahepatic eholestasis of pregnancy （ICP）. A total of 131 ICP patients were divided into mild and severe ICP groups according to serum total bile acid concentration. And another 100 normal subjeets during the same period were selected as control group. Their medical records and fetal prognoses were analyzed. The serum total bile acid, liver enzyme and lipid concentration of ICP patients were all significantly higher than those of the controls （ P 〈 0. 01 ）. The fetal prognoses of ICP patients were significantly different with those of controls （ P 〈 0. 05 ）. A high serum level of total bile acid of ICP patients may produce serious adverse effects on fetal prognosis.