CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells |
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Authors: | Kim Mi-Yeon Gaspal Fabrina M C Wiggett Helen E McConnell Fiona M Gulbranson-Judge Adam Raykundalia Chandra Walker Lucy S K Goodall Margaret D Lane Peter J L |
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Institution: | Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, United Kingdom. |
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Abstract: | In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen. Unlike dendritic cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-primed cells express the receptors for these TNF ligands and preferentially survive when cocultured with these cells. Furthermore, we show that the preferential survival of OX40(+) T cells and support of memory T cell help for B cells are linked to their association with CD4(+)CD3(-) cells in vivo. |
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