| 酸枣仁总生物碱镇静催眠作用的实验研究 |
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| 引用本文： | 符敬伟,乔卫,陈朝晖.酸枣仁总生物碱镇静催眠作用的实验研究[J].天津医科大学学报,2005,11(1):52-54. |
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| 作者姓名： | 符敬伟 乔卫 陈朝晖 |
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| 作者单位： | 1. 天津医科大学药学院,天津,300070
2. 天津市儿童医院 |
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| 摘 要： | 目的：考察酸枣仁总生物碱对小鼠的镇静催眠作用。方法：采用镇静催眠观察对小鼠自主活动，协同戊巴比妥钠对小鼠睡眠作用的影响。结果：酸枣仁总生物碱(25～100mg／kg)灌胃可减少小鼠自发活动，显著延长阈上剂量戊巴比妥钠致小鼠睡眠时间，增加阈下剂量戊巴比妥钠睡眠动物数。结论：提示生物碱为酸枣仁中枢抑制作用的有效部位。
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| 关 键 词： | 酸枣仁 总生物碱 镇静催眠 |
| 文章编号： | 1006-8147(2005)01-0052-03 |
| 修稿时间： | 2004年9月27日 |
Study on sedative and hyponotic effect of total alkaloid from Semen Zizyphi Spinosae |
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| FU Jing-wei,QIAO Wei,CHEN Zhao-hui.Study on sedative and hyponotic effect of total alkaloid from Semen Zizyphi Spinosae[J].Journal of Tianjin Medical University,2005,11(1):52-54. |
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| Authors: | FU Jing-wei QIAO Wei CHEN Zhao-hui |
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| Institution: | FU Jing-wei1,QIAO Wei1,CHEN Zhao-hui2 |
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| Abstract: | Objective: In this paper the sedative and hyponotic effects of total alkaloids were studied. Methods: sedative and hyponotic as well as anticonvulsant experiments were made to observe the effect of total alkaloid from semen zizyphi spinosae on the spontaneous motion and hyponosis in mice. Results: The result showed that total alkaloid from Semen Zizyphi Spinosae could markedly inhibit spontaneous motion,enhance the sleeping number of pentobarbital sodium (subthreshold dosage; and prolong the sleeping time of pentobarbital sodium (superthreshold dosage;. Conclusion: The total alkaloid from Semen Zizyphi Spinosae possesses obvious sedative and hyponotic effects. |
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| Keywords: | Semen Zizyphi Spinosae Total alkaloid Sedation and hyponosis |
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