尼维地平对大鼠局灶脑缺血的治疗作用

本实验探讨了尼维地平（Ｎｉｌｖａｄｉｐｉｎｅ）对大鼠局灶脑缺血的治疗作用。在氟烷麻醉下，由颈内动脉插入单尼龙线阻断大脑中动脉。阻断后１、２、３和４ｈ，皮下注射Ｎｉｌｖａｄｉｐｉｎｅ或其溶剂聚乙二醇。局灶脑缺血后１ｈ，Ｎｉｌｖａｄｉｐｉｎｅ投与组，神经缺损体征评分和脑水肿体积明显减少。局灶脑缺血３ｈ以内，Ｎｉｌｖａｄｉｐｉｎｅ投与组，皮层梗塞灶、总梗塞灶体积均较对照组明显减少。定性分析后显示：额顶皮层梗塞灶边缘部即缺血性半暗区的缩小为主。Ｎｉｌｖａｄｉｐｉｎｅ于大鼠大脑中动脉阻断３ｈ以内应用能缩小梗塞灶，可用于临床治疗急性脑梗塞。

Therapeutic effects of Nil vadipine on rat focal cerebral ischemia

The present study was conducted to investigate the therapeutic effects of Nil-vadipine on rat focal cerebral ischemia。Under halothane anesthesia,a 3-0 nylon thread was in-troduced into the internal carotid artery of the neck to occlude the left middle cerebral artery。Ei-ther Nilvadipine(3.2 mg/kg) or vehicle was adiministered subcutaneously l,2,3,and 4 hrsafter the occlusidn(Group l～4).Twenty four hrs following the occlusion, neurologic outcomesof Group l were better in Nilvadipine─treated animals than in controls.The infarct volumes ofNilvadipine─treated Group l-3 animals were smaller than those of their own controls。Comparedwith controls,the infarct size of the periphery of the fronto-parietal cortex decreased in Nilvadip-ine─treated animals。 The resuIts indicated that Nilvadipine decreased the size of infarction whenadministered within 3 hrs after an ischemic insuIt。Thus Nilvadipine can be considered a potentialtherapeutic agent for treating acute focal cerebral ischemia,and may be useful in stroke paticnts。