钙摄入与脑卒中发生风险队列研究的Meta分析

目的 系统评价钙摄入与脑卒中发生风险的相关性。方法 计算机检索电子数据库Cochrane Library、PubMed、Embase和中国期刊全文数据库、中文科技期刊全文数据库、万方数据库至2017年10月。纳入钙摄入与脑卒中发生风险的前瞻性队列研究。采用RevMan5.3进行Meta分析。结果 共纳入13篇队列研究，Meta分析显示:（1）钙摄入最高组与最低组脑卒中发病风险相对危险度合并效应量（RR = 0.92，95% CI: 0.83～1.01），差异无统计学意义，钙摄入量与脑卒中发生风险无明显相关性；（2）亚组分析发现膳食钙摄入最高组与最低组脑卒中发生风险合并效应值（RR = 0.82,95%CI:0.73～0.91,P＜0.01）差异有统计学意义,即高膳食钙摄入可降低脑卒中发生风险；（3）在亚洲人群中，高钙摄入与低钙摄入相比，差异具有统计学意义，高钙摄入时脑卒中发生风险明显降低（RR = 0.78, 95%CI:0.65～0.94, P＜0.01）。结论 钙摄入与脑卒中发生风险无明显相关性，但在亚洲人群或膳食钙摄入亚组中，钙摄入是脑卒中发生风险的保护因素。

Calcium intake and stroke risk: a meta-analysis of 13 cohort studies

Objective To evaluate the relationship between calcium intake and risk of stroke. Methods Cochrane Library, PubMed, Embase, CNKI, VIP and Wanfang were searched with relevant terms (up to October 2017). Cohort study of calcium supplement and stroke risk was included. RevMan5.3 software was used for statistical analysis. Results Thirteen cohort studies met inclusion criteria and were analyzed. The results of meta-analysis showed as follows: 1. The difference in stroke risk had no statistical significance between highest calcium intake group and lowest calcium intake group (RR=0.92, 95% CI: 0.83-1.01), indicating that there was no significant correlation between calcium intake and stroke risk. 2. The difference in stroke risk had statistical significance between highest calcium intake group and lowest calcium intake group in dietary calcium subgroup(RR=0.82, 95% CI: 0.73-0.91, P<0.01). 3. In the Asian population, the highest calcium intake was statistically significant compared with the lowest group,(RR=0.78, 95% CI: 0.65-0.94, P<0.01). Conclusion There was no significant correlation between calcium intake and risk of stroke, but high calcium intake was a protective factor for stroke in people of Asians and dietary calcium.