食欲素系统在睡眠障碍影响认知功能的研究进展

睡眠是人体的一个主动过程,睡眠时间占人类一生的三分之一,每日的睡眠-觉醒周期为生物节律提供了控制全身稳态和体内动力学的基础,因此,睡眠障碍会造成许多不良后果,认知功能下降就是其中之一。食欲素是下丘脑产生的一种神经肽,有报道称,以食欲素系统为靶点的药理学干预可改善睡眠障碍,在预防和延缓认知功能方面有很大潜力。本文将近年来与食欲素系统、睡眠障碍及认知功能相关的研究进行综述,为将食欲素系统在睡眠障碍影响认知功能方面的研究提供新思路。

Effect of orexin system on cognitive function of sleep disorder

Sleep is an active process of human body,accounting for a third of human life tieme.The daily sleep-wake cycle provides the basis for controlling the homeostasis and dynamics of human body.Therefore,sleep dysfunction can cause many adverse consequences,including cognitive decline.Orexin is a neuropeptide produced by hypothalamus.It has been reported that pharmacological interventions targeting the orexin system have great potential in improving sleep disorders,preventing and delaying the decline of cognitive function.In this paper,recent studies on orexin system,sleep dysfunction and cognitive function was reviewed,which provided new ideas for the effect of orexin system on cognitive function of sleep disorders.