The WD Gene for Wilson's Disease Links to the Hepatitis of LEG Rats |
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| Authors: | Takao Ono Shigeyuki Takada Michihiro C Yoshida |
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| Institution: | Chromosome Research Unit, Faculty of Science, Graduate School of Environmental Earth Science, Hokkaido University, North 10 West 8, Kita-ku, Sapporo 060;Department of Cytogenetics, Division of Biological Sciences, Graduate School of Environmental Earth Science, Hokkaido University, North 10 West 8, Kita-ku, Sapporo 060 |
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| Abstract: | LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross (WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEG rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper-transporting ATPase expressed in the liver. |
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| Keywords: | LEC rat hts Wilson's disease gene |
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