| 以抗血管生成为基础的节律化疗研究进展 |
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| 引用本文： | 王云 杜伟 李醒亚. 以抗血管生成为基础的节律化疗研究进展[J]. 陕西肿瘤医学, 2007, 15(10): 1518-1520 |
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| 作者姓名： | 王云 杜伟 李醒亚 |
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| 作者单位： | [1]泰山医学院生命科学研究所,山东泰安271000 [2]郑州大学第一附属医院肿瘤科,河南郑州450052 |
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| 摘 要： | 除增殖的肿瘤细胞和其它多种正常细胞外,传统细胞毒性化疗药物也影响肿瘤血管内皮细胞的生长。当给予节律化疗,即频繁或持续给予低剂量化疗药物且不伴较长间歇期时,化疗的抗血管生成作用最强,尤其是与特异性抗血管生成药物合用时。现就其抗血管生成作用及其机制、联合用药及临床试验现状作一综述。
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| 关 键 词： | 肿瘤 节律化疗 抗血管生成 |
| 文章编号： | 1672-4992-（2007）10-1518-03 |
| 收稿时间： | 2006-11-29 |
| 修稿时间： | 2007-01-23 |
Metronomic chemotherapy and its antiangiogenic effects |
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| WANG Yun;DU Wei;LI Xing-ya. Metronomic chemotherapy and its antiangiogenic effects[J]. Shaanxi Oncology Medicine, 2007, 15(10): 1518-1520 |
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| Authors: | WANG Yun DU Wei LI Xing-ya |
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| Abstract: | the proliferating tumor cells and many other normal cells,the traditional cytoxic drugs can affect the endothelial cells of tumor vessel.When giving metronomic chemotherapy,that is administering chemotherapy drugs more frequently and at lower dosage and without long rest periods,chemotherapy has the strongest antiangiogenic effect,especially used with drugs targeted to angiogenic endothelial cells.Now we review the antiangiogenic effect of metronomic chemotherapy and its mechanism,combined therapy and clinical trial. |
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| Keywords: | neoplasm Metronomic chemotherapy antiangiogenic |
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