Influence of sertraline on the antinociceptive effect of morphine, metamizol and indomethacin in mice

Interaction between analgesic and various psychotropic drugs constitute a subject of many research investigations. Literature data considering this issue are often inconsistent. Sertraline is one of the most potent drugs in the family of selective serotonine reuptake inhibitors (SSRIs). The influence of sertraline (5 mg/kg) on antinociceptive effect of morphine (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg or 1.4 mg/kg) was investigated in a mouse model using the tail-flick and hot-plate tests. All drugs were injected intraperitoneally. Sertraline was administered to mice 30 min before applying the analgesic drugs. Measurement of nociception was performed within 2 h after sertraline administration. The research studies were futher conducted with multiple (14 days) drug dosage. Sertraline after single dose increased the antinociceptive effect of morphine (in the hot-plate test) and metamizol and indomethacin (only in the tail-flick test). Sertraline after 14 day administration decreased analgesic effect of morphine (only in the hot-plate test). Sertraline applied for 14 days increased the antinociceptive effect of indomethacin. Sertraline alone after multiple doses increased pain reaction time. The results of experiments suggest the role of sertraline in nociception and possibility of interaction between sertraline and analgesic drugs.