肠道菌群调节肠道MicroRNA治疗骨质疏松症

骨质疏松症是以骨量减少,骨组织结构退化进而极易导致骨质疏松性骨折的一类疾病。严重影响患者生活质量,同时也带来了极大的经济负担。近年来有关调节肠道菌群进而干预骨质疏松症的研究逐渐兴起。炎症性肠病是由肠道菌群失调引起的炎症免疫变态反应,而炎症性肠病与骨量丢失密切相关。近来有研究表明肠道菌群与肠道MicroRNA直接的相互作用可以治疗炎症性肠病。为此,我们提出设想,肠道菌群可能调节肠道MicroRNA具有治疗骨质疏松症潜力,现从肠道菌群与骨质疏松症;MicroRNA与骨质疏松症;肠道菌群与MicroRNA;炎症性肠病与骨质疏松症四方面展开综述,支持肠道菌群通过调节肠道MicroRNA治疗骨质疏松症的观点,为骨质疏松症治疗提供新思路。

Gut microbiota regulates intestinal MicroRNA for the treatment of osteoporosis

Osteoporosis is a kind of disease in which the bone mass decreases and the bone tissue structure degrades, which can easily lead to osteoporotic fracture. It not only seriously affects the quality of life of patients, but also brings great economic burden. In recent years, studies on the regulation of gut microbiota and the intervention of osteoporosis have gradually emerged. Inflammatory bowel disease (IBD) is an inflammatory immune allergy caused by the imbalance of gut microbiota, and IBD is closely related to bone loss. Recent studies have shown that direct interaction between gut microbiota and intestinal MicroRNA can treat inflammatory bowel disease. Therefore, we hypothesized that gut microbiota may regulate intestinal MicroRNA and have the potential to treat osteoporosis. An overview was conducted from the four aspects including gut microbiota and osteoporosis, MicroRNA and osteoporosis, gut microbiota and MicroRNA, and inflammatory bowel disease and osteoporosis, supporting the idea that gut microbiota can regulate intestinal MicroRNA for the treatment of osteoporosis and providing new ideas for the treatment of osteoporosis.