| BTLA:一个新发现的CD28超家族共刺激分子 |
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| 引用本文： | 周玲,张翔,何广胜,吴德沛.BTLA:一个新发现的CD28超家族共刺激分子[J].国际免疫学杂志,2007,30(3):185-188. |
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| 作者姓名： | 周玲 张翔 何广胜 吴德沛 |
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| 作者单位： | 215006,苏州大学附属第一人民医院,江苏省血液病研究所 |
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| 基金项目： | 江苏省青年科技创新人才基金（BK2004424）;江苏省135重点学科开放基金（135XY0416） |
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| 摘 要： | BTLA是新近发现的一个CD8超家族共刺激分子，它与CTLA-4、PD-1有相似的结构和功能，对T细胞活化起负性调控作用，同时还可作为胸腺细胞阳性选择的早期标志。研究发现BTLA可与HVEM直接结合，目前多认为HVEM是BTLA的配体。BTLA—HVEM相互作用沟通了CD28及TNFR两个共刺激分子超家族，是一个比较特别的．CD28超家族分子。
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| 关 键 词： | CD28超家族 共刺激分子 BTLA HVEM |
| 修稿时间： | 2006-04-11 |
BTLA,a novel CD28 superfamily member |
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| ZHOU Ling, ZHANG Xiang.BTLA,a novel CD28 superfamily member[J].International Journal of Immunology,2007,30(3):185-188. |
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| Authors: | ZHOU Ling ZHANG Xiang |
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| Institution: | Department of hematology, First Affiliated Hospital, Suzhou University, Jiangsu Institute of Hematology, Suzhou 215006, China |
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| Abstract: | BTLA is a novel costimulator of CD28 superfamily which is structurally and functionally similar to the other two T cell inhibitory receptors, cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1 ). It is the negative costimulator that regulates the activation of T cells and also the early marker of positive selection of thymus cells. HTVM has been proposed to be the ligand of BTLA because of its direct interaction with BTLA. Since the ligation of BTLA and HVEM is the first example of TNFR family member as the ligand for CD28 family member, BTLA is a special costimulator. |
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| Keywords: | CD28 superfamily Costimulator BTLA HVEM |
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