子宫癌肉瘤12例临床分析

背景与目的:子宫癌肉瘤也称子宫同源性恶性苗勒氏管混合瘤,发病率低,预后差。本研究旨在探讨子宫癌肉瘤的临床特点、诊断、治疗及预后,以提高对该病的认识和治愈率。方法:回顾性分析中山大学肿瘤防治中心1978年1月～2004年1月收治的12例子宫癌肉瘤的临床资料并对12例患者进行随访。结果:12例子宫癌肉瘤患者中,宫颈癌肉瘤2例,宫体癌肉瘤10例。宫颈癌肉瘤主要临床表现为接触性阴道出血,宫体癌肉瘤则为不规则阴道流血和绝经后阴道流血。确诊需要依据病理组织检查。12例患者均接受手术,其中8例术后辅助化疗,2例术后辅助放疗。2例宫颈癌肉瘤中1例于术后2年内死亡;10例宫体癌肉瘤1、3、5年生存率分别为80.0%、50.0%、50.0%。结论:手术是子宫癌肉瘤的主要治疗方法,预后与手术病理分期、治疗方式有关。

Clinical analysis of 12 cases of uterine carcinosarcoma

BACKGROUND & OBJECTIVE: Uterine carcinosarcoma, also known as malignant mixed mullerian tumors, is an uncommon neoplasm that carries a poor prognosis. This study was to analyze the clinical manifestation, diagnosis, treatment and prognosis of this disease. METHODS: Clinical data of 12 uterine carcinosarcoma patients, diagnosed in Cancer Center of Sun Yat-sen University from 1978 to 2004, were analyzed. RESULTS: Of the 12 cases of uterine carcinosarcoma, 2 were in the cervix, 10 in the corpus uteri. The main clinical manifestation of cervical carcinosarcoma was contact vaginal bleeding. Carcinosarcoma in the corpus uteri manifested abnormal vaginal bleeding and postmenstrual bleeding. Diagnosis depended on pathology. Twelve patients undergone operation. Eight patients received chemotherapy and 2 received radiotherapy after operation. One cervical carcinosarcoma patient died within 2 year. The 1-, 3-, and 5-year survival rates of the 12 patients were 80.0%, 50.0%, and 50.0%,respectively. CONCLUSIONS: Primary surgery is the main treatment for uterine carcinosarcoma. The prognosis of uterine carcinosarcoma is associated with surgicopathologic stage and treatment modalities.