仙鹤草抗突变和抑制肿瘤作用实验研究

目的:对仙鹤草的抗突变和抗肿瘤作用进行研究,为开发仙鹤草的保健作用提供依据。方法:以小鼠骨髓细胞微核实验和睾丸染色体畸变实验观察仙鹤草的抗突变作用,以S-180和H-22移植性肿瘤观察仙鹤草的抗肿瘤效果。结果:仙鹤草对环磷酰胺诱发的小鼠骨髓细胞微核发生和丝裂霉素诱发的小鼠睾丸细胞染色体畸变均有明显的抑制效果。对S-180和H-22小鼠移植性肿瘤生长也有明显的抑制作用。结论:仙鹤草对体细胞和生殖细胞的DNA损伤均有保护作用,对小鼠移植性肿瘤也有一定的抑瘤作用。

Study on Antimutangenic and Antineoplastic Effect of Hairyvein Agrimony

Objective: The antimutangenic and antineoplastic effects of hairyvein agrimony were studied to provide scientific basis for exploiting health function of hairyvein agrimony . Methods: Antimutangenic effect of hairyvein agrimony was testified based on the mice bone marrow cell micronuclei test and the mice testis chromosome aberration ; Antimutangenic effect of hairyvein agrimony was testified based on S-180 and H-22 tumor cell transplanting test in mice. Results: The micronuclei frequency induced by cyclophosphamidum in mouse bone marrow cells and chromosome aberration frequency induced by mitomycine were both inhibited significantly by hairyvein agrimony. Conclusion: Hairyvein agrimony had preventive effects on DNA damage in body cell and germinal cell, and had a inhibitory effect on tumor growth.