| 黄芪总皂苷与赤芍总苷协同抗血栓作用 |
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| 引用本文： | 徐先祥,刘青云,彭代银,夏伦祝,高家荣.黄芪总皂苷与赤芍总苷协同抗血栓作用[J].中国实验方剂学杂志,2002,8(3):35-37. |
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| 作者姓名： | 徐先祥 刘青云 彭代银 夏伦祝 高家荣 |
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| 作者单位： | 1. 安徽中医学院第一附院药剂科,安徽,合肥,230032
2. 安徽中医学院药学系,安徽,合肥,230038 |
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| 摘 要： | 运用肺栓塞、动脉血栓形成、脑血栓形成三种实验性血栓形成模型 ,观察黄芪总皂苷 (AS)和赤芍总苷 (TSP)以各种剂量配伍时的作用 ;结果AS和TSP均具有不同程度抗各种实验性血栓形成作用或趋势 ,配伍后作用更佳 ,抗凝作用则源于赤芍总苷 ,应用二因素五水平均匀设计方法观察到AS 5 0mg kg和TSP 15 0mg kg配伍时抗动脉血栓形成作用最佳 ,该剂量下两药配伍对于大鼠脑血栓有相加的保护作用。表明AS和TSP有协同抗血栓形成作用。
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| 关 键 词： | 黄芪总皂苷 赤芍总苷 抗血栓 协同作用 |
| 文章编号： | 1005-9903(2002)03-0035-04 |
| 收稿时间： | 2001/8/28 0:00:00 |
| 修稿时间： | 2001年8月28日 |
Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia |
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| XU Xian-xiang,LIU Qing-yun,XU Xian-jun,PENG Dai-ying,XIA Lun-zhu,GAO Jia-rong.Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia[J].China Journal of Experimental Traditional Medical Formulae,2002,8(3):35-37. |
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| Authors: | XU Xian-xiang LIU Qing-yun XU Xian-jun PENG Dai-ying XIA Lun-zhu GAO Jia-rong |
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| Institution: | XU Xian-xiang 1,LIU Qing-yun 2,XU Xian-jun 3,PENG Dai-ying 2,XIA Lun-zhu 1,GAO Jia-rong 1 |
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| Abstract: | Objective:To investigate the interactions between astragalosides (AS) and total saponins of paeonia(TSP) with various dosage. Methods:Using pulmonary embolism, artery thrombosis and cerebral thrombosis experimental thrombosis models. Results and Conlusion:AS and TSP showed apparent anti-thrombosis effects, and better when they were used together. The anti-thrombotic effects on artery thrombosis were the strongest when AS at dose of 50mg/kg co-operated with TSP at dose of 150mg/kg with uniform design method. |
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| Keywords: | Astragalosides Total Saponins of Paeonia Anti-thrombotic Synergistic effect |
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