Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats |
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Authors: | Joyce Alencar Santos,Aline Arruda,Magaiver Andrade Silva,Claudia Andrea Lima Cardoso,Maria do Carmo Vieira,Câ ndida Aparecida Leite Kassuya,Arielle Cristina Arena |
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Affiliation: | 1. School of Health Sciences, Federal University of Grande Dourados, Dourados-MS, Brazil;2. Mato Grosso do Sul State University, Dourados-MS, Brazil;3. School of Agrarian Sciences, Federal University of Grande Dourados, Dourados-MS, Brazil;4. Department of Morphology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Distrito de Rubião Junior, S/N, Caixa Postal 510, CEP 18618970, Botucatu-SP, Brazil |
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Abstract: | Ethnopharmacological relevanceJacaranda decurrens subsp. symmetrifoliolata Farias and Proença (Bignoniaceae) is a species traditionally used for the treatment of inflammatory diseases. However, until this moment, there is no scientific evidence of these effects.Aim of studyTo evaluate the anti-inflammatory effects of hydroethanolic root extract of Jacaranda decurrens in rats and to determine the safe of this plant after acute exposure.Materials and methodsThe acute toxicity of Jacaranda decurrens root extract (EJD) was evaluated by oral administration to male rats as single doses of 0; 500; 1000 or 2000 mg/kg body weight. General behavior and toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in carrageenan-induced inflammatory paw edema and myeloperoxidase activity in male rats.ResultsNo signs of acute toxicity were observed, indicating that the LD50 is greater than 2000 mg/kg. EJD (100 and 300 mg/kg) significantly reduced edema formation and at higher dose, the reduction was similar to dexamethasone. A significant decrease in myeloperoxidase activity was also observed.ConclusionsThe present study shows that Jacaranda decurrens extract has anti-inflammatory properties in rats without causing acute toxicity. These properties observed may be due to the presence of bioactive constituents such as ursolic acid. |
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Keywords: | Jacaranda decurrens Inflammation Paw edema Carrageenan Toxicity |
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