Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study |
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| Authors: | Bourke Liam Thompson Georgia Gibson Debra J Daley Amanda Crank Helen Adam Ian Shorthouse Andrew Saxton John |
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| Affiliation: | aeNIHR Cardiovascular Biomedical Research Unit, Sheffield Foundation Trust National Health Service Trust, Sheffield, United Kingdom;bFaculty of Health and Wellbeing, Sheffield Hallam University, Collegiate Crescent Campus, Sheffield, United Kingdom;cDepartment of Colorectal Surgery, Sheffield Teaching Hospitals National Health Service Foundation Trust, Northern General Hospital, Sheffield, United Kingdom;dPrimary Care Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;eSchool of Allied Health Professions, University of East Anglia, Norwich, United Kingdom |
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| Abstract: | Bourke L, Thompson G, Gibson DJ, Daley A, Crank H, Adam I, Shorthouse A, Saxton J. Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study.ObjectiveTo investigate the feasibility of a pragmatic lifestyle intervention in patients who had recently completed surgery and chemotherapy for colon cancer and to obtain preliminary data of its impact on important health outcomes.DesignA prospective, randomized, controlled pilot trial.SettingUniversity rehabilitation facility.ParticipantsEighteen (N=18) colon cancer survivors (mean age=69y; range, 52–80y), Dukes stage A to C.InterventionsParticipants were randomized 6 to 24 months postoperatively to either a 12-week program of combined exercise and dietary advice or standard treatment.Main Outcome MeasuresExercise and dietary behavior, fatigue, health-related quality of life (QOL), aerobic exercise tolerance, functional capacity, muscle strength, and anthropometery were assessed at baseline and immediately after the intervention.ResultsAdherences to supervised and independent exercise during the intervention were 90% and 94%, respectively, and there was low attrition (6%). The lifestyle intervention elicited improvements in exercise behavior (P=.068), fatigue (P=.005), aerobic exercise tolerance (P=.010), chair sit-to-stand performance (P=.003), and waist-to-hip ratio (P=.002). A positive change in dietary fiber intake (P=.044) was also observed in the intervention group. No change in QOL was observed (P=.795).ConclusionsThese preliminary results suggest that a pragmatic lifestyle intervention implemented 6 to 24 months after primary treatment for colon cancer was feasible. We observed a significant impact on dietary behavior, fatigue, aerobic exercise tolerance, functional capacity, and waist-to-hip ratio. These findings need to be confirmed with a larger-scale definitive randomized controlled trial. |
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| Keywords: | Colonic neoplasms Diet Exercise Fatigue Rehabilitation |
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