幽门螺杆菌和高敏C反应蛋白与冠心病关系的Logistic回归分析

目的：探讨上海人群中幽门螺杆菌（Helicobacter pylori，Hp）感染与冠心病的关系。方法: 对入选的冠心病患者和正常对照进行仔细的体格检查和问卷调查。采用Logistic回归研究Hp感染和血清超敏C反应蛋白（hypersensitive C-reactive protein， hs-CRP）水平在冠心病中的优势比。结果: 冠心病患者的Hp感染率和hs CRP水平明显高于对照组（χ²=6.63,t=22.82，P＜0.05）。经年龄和性别校正后的Hp感染率和血清hs-CRP水平在冠心病中优势比分别为1.146（0.722-1.819），1.073（0.969-1.187）。经全参数校正后的Hp感染率和血清hs-CRP水平在冠心病中优势比分别为1.132（0.682-1.877），1.026（0.918-1.147）。结论: Hp感染率和血清hs-CRP水平与冠心病关系不明确，Hp感染率和血清hs-CRP水平不可以作为上海人群冠心病的风险因子。

Logistic regression of the relationships between Helicobacter pylori and hs-CRP with coronary heart disease

Objective: To investigate the relationship between Helicobacter pylori(Hp) infection and coronary heart disease(CHD) in the people of Shanghai.MethodsThe selected patients and controls underwent a standard physical examination and questionnaire. Odds ratios(OR) of Hp infection ratio and the hypersensitive C-reactive protein (hs-CRP) level for coronary heart disease were analyzed by logistic regression. Results :Hp infection ratio and hs-CRP level in CHD cases were significantly higher than that of controls(χ²=6.63,t=22.82, P＜0.05). Age and sex adjusted odds ratios of Helicobacter pylori infection ratio and the hs-CRP level for CHD were 1.146(0.722-1.819)，1.073(0.969-1.187), respectively. Fully adjusted odds ratios of Helicobacter pylori infection ratio and the hs-CRP level for CHD were 1.132(0.682-1.877), 1.026(0.918-1.147),respectively. ConclusionsThere were no obvious associations between Hp infection ratio and hs-CRP level with coronary heart disease. Hp infection and hs-CRP level should not be considered as the risk factors of CHD for Shanghai people.