HER2/neu和Akt2在胃癌中的表达及意义

 目的检测HER2/neu和Akt2蛋白在胃癌及正常胃组织中的表达，分析二者与胃癌临床病理指标间的关系。方法应用免疫组化方法检测HER2/neu和Akt2蛋白在80例胃癌及40例正常胃组织中的表达。结果HER2/neu和Akt2蛋白阳性表达率胃癌中分别为17.50%和67.50%，正常胃组织中分别为0和5.00%，胃癌组织与正常胃组织比较HER2/neu和Akt2蛋白阳性表达率的差异均有统计学意义（P <0.05）；胃癌中，HER2/neu的表达与胃癌Lauren分型、组织学分化程度有关（P <0.05），与临床分期、淋巴结转移及浆膜浸润无关（P >0.05）；而Akt2的表达与胃癌Lauren分型、组织学分化程度、临床分期及淋巴结转移有关（P <0.05），与浆膜浸润无关（P >0.05）。HER2/neu及Akt2在胃癌中的表达有一定的一致性（χ² =4.97,P <0.05）。结论HER2/neu和Akt2蛋白在胃癌中有表达，二者的表达可能与胃癌的不良预后有密切关系，HER2/neu及Akt2在胃癌中的表达具有一定的一致性。

Significance and Expressions of HER2/neu and Akt2 Proteins in Gastric Carcinoma

Objective To study the expressions of HER2/neu and Akt2 proteins in gastric carcinoma and their relationship with clinicopathological factors. Methods HER2/neu and Akt2 proteins were measured in gastric carcinoma (n=80) and normal gastric tissues (n=40) by immunohistochemical staining. Results In gastric carcinoma,positive rates of HER2/neu and Akt2 proteins were 17.50% and 67.50%; in normal gastric tissue,the positive rates were 0 and 5.00%,both of the results had significant differences (P<0.05). In gastric carcinoma,HER2/neu expression was related with the Lauren’s classification and histological grading (P<0.05); no association was observed between HER2/neu expression and clinical stage,lymph nodes metastasis as well as serosal invasion (P>0.05). The expression of HER2/neu showed certain consistence with Akt2 (χ²=4.97,P<0.05). Conclusion There were HER2/neu and Akt2 expressions in gastric carcinoma. The expressions of HER2/neu and Akt2 may play an important role in the poor prognosis and progression of gastric carcinoma. The expression of HER2/neu showed a definite consistence with Akt2.