外源性磷酸肌酸对力竭运动小鼠的影响

目的：观察电针丰隆穴对高脂血症大鼠炎症因子细胞间粘附分子（ICAM-1）、单核细胞趋化因子（MCP-1）含量的影响。方法：SD大鼠50只，随机分为空白对照组（A组）、模型对照组（B组）、模型饮控组（C组）、模型电针组（D组）、模型饮控＋电针组（E组）各10只。干预60d后，测定血脂含量及ICAM1、MCP-1的含量。结果：与A组比较，B组大鼠血浆胆固醇（TC）、低密度脂蛋白（LDL-C）含量明显上升（均P％0．01），高密度脂蛋白（HDI．C）明显下降（均P％0．01）；C、D组大鼠血浆TC、LDL-C与B组比较均明显下降（P〈0．05，0．01），但较A组均明显升高（均P〈0．01）；E组大鼠血浆中TC、LDL-C含量均较B、C组明显降低（均P〈0．01）。除E组外，其余各组大鼠腹腔巨噬细胞及ICAM1、MCP-1含量与A组比较均明显增加（P〈0．05，0．01），且B、C组增加更为显著（均P〈0．01）；与B、C组比较，E组巨噬细胞及ICAM-1、MCP-1含量显著下降（均P〈0．01）。结论：电针丰隆穴能够明显下调高脂血症大鼠血浆中的TC、LDL-C、巨噬细胞及ICAM、MCP-1的含量，从而达到对高脂血症的治疗作用。

Effect of exogenous phosphocreatine on exhaustive exercise mice

Objective：To study the effect of electroacupuncture at the ＂Fenglong＂ on inflammatory factors ICAM1 and MCP1 of rats with hyperlipemia （HLP）. Methods：Fifty health male SD rats were randomly divided into 5 groups： normal control group （A）, model control group （B）, model -- normal diet group （ C）, model ＋electroacupuncture group （D）, model＋normal diet@electroacupuncture group （E） （n=10 each group）. After intervention for 60 days,blood fat and the expression of ICAM-1 and MCP-1 were detected. Results：As compared with group A,the contents of TC and LDL-C were significantly increased and HDL-C significantly reduced in group B（P〈0.05,0. 01）. The contents of TC and LDL-C were significantly decreased in groups C and D as compared with group B, and those in groupsB, C, D were significantly higher than in group A （all P〈0.01）. As compared with groups B and C, the contents of TC and LDLC were significantly redeuced in group E（ all P〈0.01）. The number of macrophages, the expression levels of ICAM-1 and MCP-1 in groups B, C, D were obviously increased as compared with group A（P〈0.05,0. 01 ）, more significantly in groups B and C（all P〈0.01）. The number of macrophages, and the expression levels of ICAM-1 and MCP-1 in group E were obviously decreased as compared with group B and C（all P〈0.01）. Conclusion： Electroaeupuncture at ＂Fenglong＂ can notably decrease the contents of TC and LDI.-C,the number of macrophages, and the expression levels of ICAM-1 and MCP-1, thereby have therapeutical effect on hyperlipemia.