基质金属蛋白酶-9与2型糖尿病大血管病变的关系及辛伐他汀的治疗作用

目的　探讨基质金属蛋白酶 9(MMP 9)与 2型糖尿病大血管病变的关系和辛伐他汀血管保护作用的机制。方法　采用酶联免疫吸附法测定了 4 0名正常对照者和 80例 2型糖尿病患者 (其中单纯 2型糖尿病者4 0例 ,大血管病变者 4 0例 )血清中的MMP 9,分析其与大血管病变之间的关系 ,并观察辛伐他汀治疗前后MMP 9、血脂的变化。结果　大血管病变组血清中MMP 9的质量浓度显著高于单纯 2型糖尿病组和正常对照组。MMP 9与胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)、氧化低密度脂蛋白 (Ox LDL)、血压呈正相关 ,与高密度脂蛋白胆固醇 (HDL C)呈负相关。辛伐他汀治疗后血清MMP 9、TC、LDL、Ox LDL明显下降。结论　血清中MMP 9质量浓度的检测对监测 2型DM大血管病变的发生、发展有重要的临床意义。辛伐他汀通过降低血清MMP 9的质量浓度发挥其对血管的保护作用

Relationship between matrix metalloproteinase-9 and type 2 diabetic macroangiopathy and the effect of Simvastatin

Objective To investigate the association between matrix metalloproteinase 9(MMP 9) and type 2 diabetic macroangiopathy and explain the mechanism of Simvastatin protective effects on blood vessel.Methods The serum MMP 9 was determined by ELISA in 40 healthy controls and 80 type 2 diabetes(including 40 type 2 diabetic macroangiopathy and 40 type 2 diabetes without complications) before and after Simvastatin treatment.Results The serum MMP 9 in type 2 diabetic macroangiopathy was higher than that in type 2 diabetes without complications and healthy controls.Serum MMP 9 was correlated positively with TC,LDL C,Ox LDL and blood pressure and correlated negatively with HDL C. After Simvastatin treatment,the levels of serum MMP 9 were reduced and serum TC,LDL C and Ox LDL were also decreased.Conclusion MMP 9 may play an important role in the development and progression of type 2 diabetic macroangiopathy.The protective effects of Simvastatin on blood vessel partly attribute to its lowering of serum MMP 9.