miRNA-143在非小细胞肺癌组织中的表达

目的: 探讨微小RNA(miRNA)-143在非小细胞肺癌(NSCLC)组织中的表达水平及其与临床病理特征之间的关系.方法: 选取40例NSCLC组织及其癌旁组织,采用实时荧光定量聚合酶链反应技术检测miRNA-143的表达水平,并分析其与临床病理特征之间的关系.结果: miRNA-143在NSCLC组织中的表达水平低于癌旁组织(P<0.05);miRNA-143的表达在不同年龄、性别、组织学类型、分化程度、TNM 分期间的差异均无统计学意义(P>0.05).NSCLC伴淋巴结转移的肺癌组织中miRNA-143的表达水平低于NSCLC不伴淋巴结转移的肺癌组织(P<0.05).结论: miRNA-143在NSCLC组织中表达下调,且可能与肺癌细胞的转移有关.

The expression of miaroRNA-143 in non-small cell lung cancer tissue

Objective： To explore the expression of micro RNA（ miRNA）-143 in non-small cell lung cancer（ NSCLC） tissue and relationship with clinicopathological features of tissue. Methods： The expression levels of miRNA-143 in NSCLC and adjacent cancerous tissue of 40 cases were detected by real-time PCR. The relationship of miRNA-143 expression with clinicopathological features of tissue was analyzed. Results： The expression of miRNA-143 in NSCLC tissue was significantly lower than that in adjacent cancerous tissue（ P 〉0.05）. The expression differences of miRNA-143 in different ages,gender,histologic types,differentiation degrees and TNM stages were not statistical significance（ P〈0.05）. The expression level of miRNA-143 in NSCLC tissue with lymph node metastasis was lower than that in NSCLC tissue without lymph node metastasis（ P〈0.05）. Conclusions： The expression level of miRNA-143 in NSCLC tissue decreases,which may be correlated with the cell metastasis of lung cancer.