Neutrophils are gatekeepers of mucosal immunity |
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Authors: | Lakmali M. Silva Tae Sung Kim Niki M. Moutsopoulos |
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Affiliation: | Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA |
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Abstract: | Mucosal tissues are constantly exposed to the outside environment. They receive signals from the commensal microbiome and tissue-specific triggers including alimentary and airborne elements and are tasked to maintain balance in the absence of inflammation and infection. Here, we present neutrophils as sentinel cells in mucosal immunity. We discuss the roles of neutrophils in mucosal homeostasis and overview clinical susceptibilities in patients with neutrophil defects. Finally, we present concepts related to specification of neutrophil responses within specific mucosal tissue microenvironments. |
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Keywords: | gastrointestinal lung mucosal immunity neutropenia neutrophils oral |
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