| 神经黏附分子NB-3在中枢神经系统中的功能 |
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| 引用本文： | 赵华,朱玲玲,范明. 神经黏附分子NB-3在中枢神经系统中的功能[J]. 国际病理科学与临床杂志, 2008, 28(1): 15-67 |
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| 作者姓名： | 赵华 朱玲玲 范明 |
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| 作者单位： | 军事医学科学院基础医学研究所脑保护和可塑性研究室,北京,100850 |
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| 摘 要： | 神经黏附分子属于免疫球蛋白超家族，它不仅在发育中与形成轴突生长方向和突触连接有关，而且在成体的突触可塑性和记忆中也发挥重要的作用。NB-3是1996年发现的神经黏附分子，属于免疫球蛋白超家族的Contactin亚家族，集中表达于神经系统。NB-3可促进神经元轴突的生长，参与少突胶质细胞的分化与成熟，促进小脑发育及功能维持。
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| 关 键 词： | 神经黏附分子 NB-3 Contactin 中枢神经系统 |
| 文章编号： | 1673-2588(2008)01-0064-04 |
| 收稿时间： | 2007-06-02 |
| 修稿时间： | 2007-06-02 |
Role of neural adhesion molecule NB-3 in central nervous system |
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| ZHAO Hua,ZHU Ling-ling,FAN Ming. Role of neural adhesion molecule NB-3 in central nervous system[J]. Journal of International Pathology and Clinical Medicine, 2008, 28(1): 15-67 |
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| Authors: | ZHAO Hua ZHU Ling-ling FAN Ming |
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| Affiliation: | Department of Brain Protection and Neural Plasticity, Insititute of Basic MedicalScience, Academy of Military Sciences, Beijing 100850, China |
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| Abstract: | Neural adhesion molecules of the immunoglobulin (Ig)-superfamily play important roles not only in the formation of axon guides and synaptic connections during development, but also in synaptic plasticity and memory in adulthood. NB-3 was firstly discovered in 1996 as a neural adhesion molecule which is a member of contactin/F3 subgroup in the immunoglobulin superfamily. NB3 is expressed exclusively in the nervous system. NB-3 can promote the outgrowth of neuron and induce in the differentiation and mature of oligodendrocyte and promote the development and maintain the function of the cerebellum. |
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| Keywords: | neural adhesion molecule NB-3 contactin central nervous system |
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