| 复方氨茶碱口服溶液中盐酸麻黄碱含量测定 |
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| 引用本文： | 楼永军. 复方氨茶碱口服溶液中盐酸麻黄碱含量测定[J]. 中国药业, 2010, 19(18): 47-48 |
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| 作者姓名： | 楼永军 |
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| 作者单位： | 浙江省食品药品检验所,浙江,杭州,310004 |
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| 摘 要： | 目的建立测定复方氨茶碱口服溶液中盐酸麻黄碱含量的高效液相色谱法。方法采用Waters C18柱（250 mm×4.6 mm,5μm）,流动相为乙腈-0.2%磷酸溶液（5∶95）,流速为1.0 mL/min,检测波长为210 nm,柱温为35℃。结果盐酸麻黄碱质量浓度在6.11～305.60μg/mL内与峰面积线性关系良好（r=1.000 0）,平均回收率为99.92%,RSD为0.58%（n=6）。结论该方法准确、简便,可用于测定复方氨茶碱口服溶液中盐酸麻黄碱的含量。
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| 关 键 词： | 复方氨茶碱口服溶液 盐酸麻黄碱 高效液相色谱法 |
Determination of Ephedrine Hydrochloride in Compound Aminophylline Oral Solution |
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| Lou Yongjun. Determination of Ephedrine Hydrochloride in Compound Aminophylline Oral Solution[J]. China Pharmaceuticals, 2010, 19(18): 47-48 |
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| Authors: | Lou Yongjun |
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| Affiliation: | Lou Yongjun ( Zhejiang Provincial Institute for Food and Drug Control, Hangzhou, Zhejiang, China 310004) |
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| Abstract: | Objective To establish a HPLC method for the determination of ephedrine hydrochloride in Compound Aminophylline Oral Solution. Methods Ephedrine hydrochloride was chromatographed on the C18 column with the temperature of 35℃, and detected at 210 nm. The used mobile phase was acetonitrile-0.2% phosphoric acid （5：95）. The flow rate was 1.0 mL/min. Results The calibration curve was linear over the range of 6.11-305.60μg/mL for ephedrine hydrochloride. The average recovery rate of ephedrine hydrochloride was 99. 92% with RSD =0. 58% （n =6）. Conclusion The established method is accurate and simple, which could be used for the determination of ephedrine hydrochloride. |
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| Keywords: | Compound Aminophylline Oral Solution ephedrine hydrochloride HPLC |
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