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| 江苏汉族群体D12S391和D6S1043基因座遗传多态性研究 | |
| 引用本文： | 刘德丽,周旭科,姜玉婷,高玉振.江苏汉族群体D12S391和D6S1043基因座遗传多态性研究[J].南通医学院学报,2011,31(2):87-88,91. |
| 作者姓名： | 刘德丽 周旭科 姜玉婷 高玉振 |
| 作者单位： | 1. 苏州大学医学部法医学系,苏州,215123;江苏省南通市公安局刑警支队 2. 苏州大学医学部法医学系,苏州,215123;浙江省诸暨市公安局刑侦大队 3. 苏州大学医学部法医学系,苏州,215123 |
| 摘 要： | 目的：调查D12S391和D6S1043基因座在江苏汉族人群的群体遗传学数据,为亲子鉴定和个人识别工作提供数据基础。方法：利用AmpF1STR Sinofiler试剂盒进行多重PCR扩增,3130型遗传分析仪进行毛细管电泳,Gen-eMapper软件自动分析各基因座的基因型。PowerStats软件计算两个基因座的等位基因频率、杂合度、个人识别机率、非父排除率及多态信息含量等群体遗传学参数,χ2检验验证Hardy-Weinberg平衡。结果：D12S391和D6S1043基因座在江苏汉族群体中均有较高的多态性,其非父排除概率和个人识别率分别为0.616、0.638、0.946和0.964。两个基因座的基因型分布均符合Hardy-Weinberg平衡（P〉0.05）。结论：本研究获得了D12S391和D6S1043两个基因座在江苏汉族群体的群体遗传学数据,分析结果显示这两个基因座适合江苏汉族群体法医学应用。 |
| 关 键 词： | 法医遗传学 短串联重复序列 D12S391 D6S1043 汉族 江苏省 |
Genetic polymorphisms of D12S391 and D6S1043 in Han ethnic group of Jiangsu Province |
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| LIU Deli,ZHOU Xuke,JIANG Yuting,GAO Yuzhen.Genetic polymorphisms of D12S391 and D6S1043 in Han ethnic group of Jiangsu Province[J].ACTA Academiae Medicinae Nantong,2011,31(2):87-88,91. | |
| Authors: | LIU Deli ZHOU Xuke JIANG Yuting GAO Yuzhen |
| Institution: | LIU Deli1,2,ZHOU Xuke1,3,JIANG Yuting1,GAO Yuzhen1(1Department of Forensic Medicine,Medical College of Soochow University,Suzhou 215123,2Department of Forensic Medicine,Nantong Public Security Bureau,Jiangsu Province,3Department of Forensic Medicine,Zhuji Public Security Bureau,Zhejiang Province) |
| Abstract: | Objective:To investigate the population genetic data of D12S391 and D6S1043 loci in Han ethnic group of Jiangsu Province and provide database reference for personal indentification and paternity testing.Methods: Genotyping were performed using AmpF1STR Sinofiler kit and capillary electrophoresis.PowerStats software was used to calculate population genetic parameters.Deviation from Hardy-Weinberg equilibrium was tested using chi-square test.Results: Allelic frequencies indicated D12S391 and D6S1043 loci were... |
| Keywords: | D12S391 D6S1043 |
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